Diglucosyl Gallic Acid: Benefits, Uses, and Product Recommendations

Let's be honest. The skincare industry right now is seeing a new ingredient emerge every week, but very few make a lasting impact. Well, Diglucosyl Gallic Acid is one of those rare gems that's here to stay! Introduced in the early 2010s, Diglucosyl Gallic Acid quickly became a go-to ingredient for its skin-brightening, anti-inflammatory, and protective properties. 

The Origins and Rise of Diglucosyl Gallic Acid

Diglucosyl Gallic Acid (DGA), also known as Trihydroxybenzoic acid glucoside (THBG), is a water-soluble compound that was first introduced in skincare by Givaudan Active Beauty, a Swiss multinational manufacturer, under the trademark name Brightenyl®. This innovative ingredient was the result of extensive research into the skin microbiome and how certain compounds can be activated by it. 

Givaudan’s development of DGA involved linking gallic acid with glucose molecules to enhance its stability and effectiveness when applied topically. The breakthrough came when researchers discovered that once DGA is applied to the skin, it is metabolized by natural skin bacteria, converting it into the active form, trihydroxybenzoic acid (THBA). This conversion allows DGA to offer targeted benefits such as brightening and anti-inflammatory effects.

The first major commercial use of DGA was by premium skincare brands that recognized its potential in addressing dark spots and skin damage caused by environmental factors. Its popularity surged as studies and user reviews began to highlight its efficacy, particularly for sensitive skin types that struggle with more aggressive treatments like hydroquinone.

How Does Diglucosyl Gallic Acid Work?

• Activation by the Stratum Microbium™: What sets DGA apart from many other skincare ingredients is how it interacts with the microbiome found on skin's surface. Stratum Microbium™ is the outermost layer of the skin's microbiome. When DGA is applied to the skin, it remains inactive until it encounters the Stratum microbium™. The naturally occuring microorganisms present in this layer convert DGA into its active form, THBA. This mechanism enhances its stability and efficacy while also reducing the risk of irritation, making it suitable for sensitive skin types.
  

• Inhibition of Melanin Production: Diglucosyl Gallic Acid is highly effective in treating hyperpigmentation by inhibiting tyrosinase, the enzyme responsible for melanogenesis (melanin synthesis). It also helps in preventing melanin transfer from melanocytes to nearby skin cells. This helps reduce dark spots and promotes an even skin color.
  

• Antioxidant Protection: It neutralizes free radical generation, which is responsible for oxidative stress and cellular damage. This protection is vital in preventing premature aging and maintaining healthy, youthful skin.
  

• Anti-Inflammatory Effects: DGA reduces skin inflammation, soothing the skin and calming redness. This is particularly beneficial for those with conditions like rosacea, acne, or sensitive skin.
  

• Photoprotection: DGA is a great photo-protectant,  When used under a sunscreen, it helps in reducing UV-induced DNA damage, dark spots, and sun damage-induced coarse wrinkles and yellowness of skin, making it an essential ingredient in sunscreens and daily moisturizers.
  

How to Incorporate Diglucosyl Gallic Acid into Your Skincare Routine

1. Suitable Skin Types: DGA is a versatile skincare ingredient and can be used by all skin types, including sensitive, oily, and acne-prone skin.

2. Product Formats: DGA is commonly found in serums, moisturizers, brightening treatments, and also as a cosmetic ingredient in many skin brightening creams. It’s especially popular in products aimed at treating hyperpigmentation and protecting against environmental damage.

3. Usage Tips: Apply products containing DGA after cleansing and before moisturizing. For optimal results, use it in combination with a broad-spectrum sunscreen during the day to maximize its photoprotective benefits. You can also safely combine it with other skin-brightening actives like kojic acid, arbutin, retinol and glycolic acid as part of your night time routine for added benefits.

Top Product Recommendations Featuring Diglucosyl Gallic Acid

1. Gundry MD® Polyphenol Dark Spot Diminisher Serum 

   This serum has some really powerful ingredients like DGA, Niacinamide, Kakadu Plum Extract, Squalane, and Licorice Root Extract to target dark spots and improve skin radiance. DGA is the hero, activated by the skin’s microbiome to reduce hyperpigmentation effectively, while Niacinamide and Licorice Root Extract work together to further brighten the skin and calm irritation. Kakadu Plum provides antioxidant protection, and Squalane ensures deep hydration, making this serum a comprehensive solution for achieving a brighter, more even complexion.

   
   

2. Sunday Riley B3 Nice 10% Niacinamide Serum This serum is designed to combat acne, brighten skin, and provide antioxidant protection. Apart from niacinamide, DGA and Turmeric Root Extract are helpful in skin brightening by targeting hyperpigmented spots and promoting an even complexion. The serum is also rich in antioxidants like Resveratrol and Madecassoside, which protect the skin from environmental stressors, while soothing ingredients like Calendula Extract and Tetrahydrocurcuminoids calm irritation and redness.
   

How To Use Diglucosyl Gallic Acid for My Skin

For Sensitive Skin: Look for products that combine DGA with soothing ingredients like aloe vera or hyaluronic acid.

For Oily Skin: Pair DGA with lightweight, oil-free formulations that include salicylic acid for added acne-fighting benefits.

For Dry Skin: Choose DGA products that also contain rich moisturizers like ceramides or shea butter to enhance hydration and barrier protection.

For Aging Skin: Use DGA alongside peptides and retinol to target fine lines and wrinkles while brightening and firming the skin.

FAQs About Diglucosyl Gallic Acid

1. Is Diglucosyl Gallic Acid Safe During Pregnancy?

DGA is generally considered safe for use during pregnancy when applied topically. It’s a gentle alternative to stronger agents like hydroquinone, making it suitable for treating pregnancy-related hyperpigmentation. Always consult with a healthcare provider before use.

2. What Are the Benefits of Diglucosyl Gallic Acid in Skincare?

DGA helps to prevent melanin synthesis. It reduces dark spots and hyperpigmentation provides antioxidant protection, soothes inflammation, and offers photoprotection against UV damage. 

3. Can Diglucosyl Gallic Acid Cause Side Effects?

While generally well-tolerated, some users might experience mild irritation, especially if they have sensitive skin.

4. How Does Diglucosyl Gallic Acid Benefit the Skin?

It brightens the skin, reduces hyperpigmentation, protects against oxidative stress, and calms inflammation, making it a highly effective ingredient for overall skin health.