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Dr. Alpana Mohta Ranka, MD, DNB, IFAAD, is a dual-board-certified dermatologist with over 90 research publications in peer-reviewed scientific journals.


Matrixyl: Understanding The Anti-Aging Skincare Ingredient

This guide provides an in-depth look at Matrixyl, comparing it with other key ingredients like Argireline, and explains how to integrate it into your skincare routine.

An abstract image of a bottle of Matrixyl

What is Matrixyl?

Matrixyl, known scientifically as Palmitoyl Pentapeptide-4 or Palmitoyl-Pentapeptide-3, is a peptide used in skincare products. Peptides, being short chains of amino acids, are fundamental in forming proteins like collagen and elastin in our skin.

Matrixyl, specifically, is designed to stimulate the production of these essential proteins, enhancing skin firmness, texture, and reducing signs of aging​​​​​​.

Benefits of Matrixyl

  1. Collagen and Elastin Production: It boosts the natural production of collagen and elastin, leading to a reduction in wrinkles and improved skin firmness​​​​.

  2. Enhanced Skin Repair and Texture: Matrixyl aids in repairing skin damage and improving texture​​​​.

  3. Increased Skin Firmness and Elasticity: Regular use leads to firmer, more elastic skin, countering sagging and aging effects​​.

Matrixyl 3000 and Matrixyl Synthe’6

Matrixyl has evolved into next-generation forms like Matrixyl 3000 and Matrixyl Synthe’6, developed by Sederma Inc. These variations offer similar anti-aging benefits and work to consolidate the skin’s extracellular matrix​​​​.

Matrixyl vs. Argireline

Matrixyl focuses on stimulating collagen production, while Argireline, another peptide, inhibits muscle contractions to reduce wrinkles. Using both ingredients in tandem offers a comprehensive anti-aging solution. For more information on Argireline, refer to our detailed article here.

Clinical Studies and Effectiveness

Studies have shown that Matrixyl significantly increases collagen production and improves the appearance of aging signs like crow’s feet​​​​.

Clinical studies on Matrixyl, a cosmetic peptide, have demonstrated its effectiveness in skin rejuvenation and wound healing. Research published in ACS Omega explored the impact of Matrixyl in different forms - patches and creams - on wound healing, revealing that both forms significantly enhanced the healing process, with the patch form showing greater efficacy in terms of collagen density and epithelialization.

Additionally, a review in Clinical, Cosmetic and Investigational Dermatology highlighted Matrixyl's role in skin rejuvenation, emphasizing its ability to promote collagen synthesis due to its smaller molecular size, which allows for better skin penetration. These studies underscore Matrixyl's potential as a key ingredient in cosmetic products for improving skin health and appearance.

How to Use Matrixyl in Your Skincare Routine

Incorporate products with at least 2% Matrixyl for effectiveness. Consistent use, whether in serums or night creams, is key to long-term results​​.

Here's a recommendation: Try the Asterwood Triple Repair serum, which contains Matrixyl, Argireline, and vitamin C.

Triple Repair Serum containing Matrixyl

Here are the steps to use Matrixyl serums:

  • Begin by thoroughly cleansing your skin to remove any impurities or makeup.

  • As part of your nighttime skincare routine, prepare to apply the face serum before your moisturizer.

  • Dispense 4-6 drops of the serum into the palm of your hand.

  • Using your fingertips, gently rub the serum onto your face, ensuring even coverage.

  • Extend the application to your neck area, massaging gently for full absorption.

  • Proceed with your regular moisturizing routine after the serum has been applied.

Safety and Side Effects

Matrixyl is well-tolerated by most skin types, including sensitive skin, and is safe for regular use​​​​.


Matrixyl stands out as a scientifically backed, effective ingredient in anti-aging skincare. When combined with Argireline, it provides robust solutions to combat aging signs, leading to youthful, radiant skin.

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